Publication / Patent


Shetty, M.; Huang, H.; Kang, J. Y. “Regioselective Synthesis of α- and γ-Amino Quinolinyl Phosphonamides Using N-Heterocyclic Phosphines (NHPs)Org. Lett. 2018, 20, ASAP, DOI: 10.1021/acs.orglett.7b03829.


Huang, H.; Kang, J. Y. “Organocatalytic Phosphonylation of In Situ Formed o-Quinone Methides”Org. Lett. 2017, 19, 5988-5991, DOI: 10.1021/acs.orglett.7b03019.

Invention Disclosure

Jun Yong Kang, Hai Huang, ”Metal-free Direct Arylation of Dialkyl Phosphonates for the Synthesis of Mixed Alkyl Aryl Phosphonates”, Filed with The Board of Regents of the Nevada System of Higher Education (NSHE) on Behalf of UNLV, 62540773, August 7, 2017

Jun Yong Kang, Hai Huang, ”Chiral N-heterocyclic Phosphordiamidic Acids (NHPAS) and Derivatives as Novel Brønsted Acid Catalysts”, Filed with The Board of Regents of the Nevada System of Higher Education (NSHE) on Behalf of UNLV (62521086)  June 16, 2017.

Huang, H.; Kang, J. Y., “Mitsunobu Reaction Using Basic Amines as Pronucleophiles” J. Org. Chem., 2017, 82, 6604-6614. DOI: 10.1021/acs.joc.7b00622


Moletti, N.; Kang, J. Y., “Synthesis of Diaryl-Diazaphosphonates via 1,6-Hydrophosphonylation of p-Quinone Methides with N-Heterocyclic Phosphine-Thioureas” Org. Lett. 2017, 19, 958–961 DOI: 10.1021/acs.orglett.7b00261

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Huang, H.; Kang, J. Y., “Oxidation-Reduction Condensation of Diazaphosphites for Carbon-Heteroatom Bond Formation Based on Mitsunobu Mechanism” Org. Lett. 201719, 544-547, DOI: 10.1021/acs.orglett.6b03709

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Huang, H.; Palmas, J.; Kang, J. Y., “A Reagent-Controlled Phospha-Michael Addition Reaction of Nitroalkenes with Bifunctional N-Heterocyclic Phosphine (NHP)-Thioureas” J. Org. Chem. 2016, 81, 11932–11939, DOI: 10.1021/acs.joc.6b02490

Table of contents

Moletti, N.; Bjornberg, C.; Kang, J. Y. “Phospha-Michael addition reaction of maleimides employing N-heterocyclic phosphine-thiourea as a phosphonylation reagent: synthesis of 1-aryl-2,5-dioxopyrrolidine-3-yl-phosphonate derivatives” Org. Biomol. Chem. 2016, 14, 10695-10704, DOI: 10.1039/C6OB01987K


Moletti, N.; Kang, J. Y. “Catalyst-free synthesis of α1-oxindole-α-hydroxyphosphonates via phospha-aldol reaction of isatins employing N-heterocyclic phosphine (NHP)-thiourea” Org. Biomol. Chem. 2016, 14, 8952-8956, DOI: 10.1039/C6OB01608A


Huang, H.; Kang, J. Y., “Amine-Catalyzed Phospha-Michael Reaction of α,β-Unsaturated Aldehydes and Ketones with Multifunctional N-Heterocyclic Phosphine-Thioureas as Phosphonylation Reagent” Org. Lett. 2016, 18, 4372–4375, DOI: 10.1021/acs.orglett.6b02121


Mulla, K.; Kang, J. Y., 1,3,2-Diazaphospholidine (N-Heterocyclic Phosphine)-Mediated Carbon-Phosphorus Bond Forming One-Pot Tandem Reaction: A Route to α-amino Phosphonates, J. Org. Chem. 201681, 4550-4558, DOI: 10.1021/acs.joc.6b00326

TOC (A Route to α-amino Phosphonates)

Kang, J.-Y.; Johnston, R. C.; Snyder, K. M.; Cheong, P. H.-Y.; Carter, R. G. Construction of Stereogenic α,α-Disubstituted Cycloalkanones via 1° Amine Thiourea Dual Catalysis: Experimental Scope and Computational Analyses J. Org. Chem. 201681, 3629-3637                                       DOI: 10.1021/acs.joc.6b00280

jo-2016-00280t_0014 TOC

Mulla, K.; Aleshire, K. L.;Forster, P. M.; Kang, J. Y. “Utility of Bi-Functional N-Heterocyclic Phosphine (NHP)-Thioureas for Metal-Free Carbon-Phosphorus Bond Construction toward Regio-, and Stereoselective Formation of Vinylphosphonates”, J. Org. Chem. 2016, 81, 77−88, DOI:10.1021/acs.joc.5b02184

NHP thiourea

El-Mansy, M. F., Kang, J.-Y.; Lingampally, R., Carter, R. G., Proline Sulfonamide-Catalyzed, Domino Process for Asymmetric Synthesis of Amino- and Hydroxy-Substituted Bicyclo[2.2.2]octanes. Eur. J. Org. Chem2016, 150–157, DOI:10.1002/ejoc.201501302[2,2,2]-bicyclo

Invention Disclosure

Jun Yong Kang, Hai Huang, Nagaraju Molleti, Functionalized Phosphonates via Michael Addition, Filed with The Board of Regents of the Nevada System of Higher Education (NSHE) on Behalf of UNLV (62376213) August 17, 2016.


Invention Disclosure

Jun Yong Kang, Karimulla Mulla, Methods and Compositions for Substituted Alpha-Aminophosphonates Analogues, Filed with The Board of Regents of the Nevada System of Higher Education (NSHE) on Behalf of UNLV (62309674) March 17, 2015.


Invention Disclosure

Jun Yong Kang, Karimulla Mulla, Kyle Aleshire, Paul M Forster, N-Heterocyclic Phosphines, Filed with The Board of Regents of the Nevada System of Higher Education (NSHE) on Behalf of UNLV (62048072) September 9, 2014.

Before UNLV

Kang, J.-Y.; Carter, R. G., Primary Amine, Thiourea-Based Dual Catalysis Motif for Synthesis of Stereogenic, All-Carbon Quaternary Center-Containing Cycloalkanones. Org. Lett. 2012, 14, 3178-3181.
Org. Lett., 2012, 14 (12), pp 3178–3181
Kang, J.-Y.; Connell, B. T., Palladium-Catalyzed Alkynylation of Secondary α-Bromo Carbonyl Compounds by the Still Coupling Reaction between sp and sp3 Carbons. J. Org. Chem. 2011, 76, 6856-6859.
J. Org. Chem., 2011, 76 (16), pp 6856–6859
Kang, J.-Y.; Connell, B. T., Efficient Synthesis of Substituted Acetylenic α,β-Epoxides Followed by Indium-Catalyzed Rearrangement to 2,3,5-Trisubstituted Furans. J. Org. Chem. 2011, 76, 2379-2383.

  • Highlighted in Synfacts20118, 607. [link]
  • Highlighted on the Organic Chemistry Portal. [link]

J. Org. Chem., 2011, 76 (7), pp 2379–2383
Kang, J.-Y.; Connell, B. T., Chromium-Catalyzed Homoaldol Equivalent Reaction Employing a Nucleophilic Propenyl Acetate. J. Am. Chem. Soc. 2010, 132, 7826-7827.

  •  Highlighted in Synfacts20107, 1063. [link]
  •  Highlighted on the Organic Chemistry Portal. [link]
  •  Highlighted in New Methods for C-C Bond Construction, February 2011. [link]

J. Am. Chem. Soc., 2010, 132 (23), pp 7826–7827
Kang, J.-Y.; Bugarin, A.; Connell, B. T., Conversion of Nitrosobenzenes to Isoxazolidines: An Efficient Cascade Process Utilizing Reactive Nitrone Intermediates” Chem. Commun. 2008, 3522-3524.

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Chem Comm, 2008