de Belle lab @
Research in the de Belle laboratory is broadly concerned with how the brain develops and functions to generate behavior. We use genetic dissection, tissue-specific ablation and transgenic techniques to examine relationships between brain structure and behavior in a model organism, the fruit fly. How and where animals form, store and access memories are among the oldest and most intriguing questions in neurobiology, and the primary focus of our investigations. Other behavior of interest include olfaction, locomotion, courtship, foraging and rhythmic phenomena. Genetic background influences on mutant phenotypes and gene expression are ongoing topics of study in our laboratory.
» Drosophila mushroom body mutants, frontal paraffin brain sections. (Left): Canton-S (+), mbr, smu. (Right): mbm (male/female), mbmB, mbmC.
Drosophila olfactory classical conditioning paradigm. (Top Half): Flies are trained with two odors, one (CS+) is paired with electric shock (US), the other (CS-) is unpaired. (Bottom Half): Memory is tested at defined time intervals after training. The normalized proportion of flies avoiding the CS+ odor provides a measure of memory. «