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BIOL 464: Bacterial Pathogenesis (Lecture syllabus - subject to change) |
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Lecture /Date |
Topics to be covered |
References |
Reading for next week |
Handouts |
BACTERIAL RELATIONSHIPS WITH ANIMALS |
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Lecture 1 Mon 8/24 |
Course outline. What are pathogens? Introduction to important terms |
Chapter 1, Ancient history takes a toll on today’s human health |
Chapter 1, Concepts of disease; use Brock’s Chapter glossary’s to find assigned definitions |
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Lecture 2 Wed 8/26 |
Why study infectious disease? A historical perspective, the situation today |
Chapter 1 |
Chapter 2; do the quiz on University of Leicester Micro website |
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Fri 8/28 |
Final Day to Drop and Receive 100% refund |
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Lecture 3 Mon 8/31 |
Approaching and studying infectious disease |
Chapter 2 |
Chapter 3; brush up on your molecular biology you’ll need this next week! |
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Lecture 4 Mon 9/2 |
Molecular approaches to the diagnosis of bacterial infections
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Chapter 3 - make sure you understand the techniques discussed. Office hours can be used if necessary. |
Chapter 3 |
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Mon 9/7 |
LABOR DAY RECESS |
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Lecture 5 Wed 9/9
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Molecular approaches continued |
Chapter 3 - make sure you understand the techniques discussed. Office hours can be used if necessary. |
Chapter 21 of Brock: Bacterial interactions with humans |
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Lecture 6 Mon 9/14 |
A survey of our normal flora: its role in protecting us against infectious disease |
Brock, Chapter 21; Todar’s online book of Bacteriology Chapter “The Bacterial Flora of Humans” |
Chapter 4 |
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Lecture 7 Wed 9/16 |
First line of Defense |
Chapter 4 |
Chapter 5 |
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Lecture 8 Mon 9/21 |
First line of Defense continued |
Chapter 5 |
Chapter 6 |
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Lecture 9 Wed 9/23 |
Second line of defense: Introduction to the adaptive immune system: Immunoglobulins |
Chapter 6 |
Review material for exam |
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Mon 9/28 |
Exam I – Lecture 1-9 |
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PRINCIPLES OF BACTERIAL PATHOGENESIS |
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Lecture 10 Wed 9/30 |
Adaptive immunity continued: T cells, B cell mucosal immunity |
Chapter 6 |
Chapter 7 |
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Fri 10/2 |
Final Day to Drop and Receive 50% refund SoLS Seminar: Dr. Erin Murphy Shigella virulence gene expression |
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Lecture 11 Mon 10/5 |
Vaccination |
Chapter 7 |
Todar |
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Lecture 12 Wed 10/7 |
Bacterial structure in relationship to pathogenicity |
Todar |
Chapter 8 |
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Lecture 13 Mon 10/12 |
Bacterial strategies of evading and surviving the defense systems of the human body; capsules; LPS; proteases, resistance to NO |
Chapter 8 (last part of chapter) |
Chapter 8 (first part) |
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Lecture 14 Wed 10/14 |
Colonization and Invasion. Pili, adhesins, resisiting anti bacterial peptides; iron acquisition; invasion and intracellular life |
Todar; Chapter 8 (first part) |
There are suitable reviews so here is a summary of what we will discuss Secretion Handout |
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Lecture 15 Mon 10/19 |
Bacterial Secretion Systems used in pathogenesis |
Secretion Handout & Appendix 1 of Salyers & Whitt |
Chapter 9; Todar |
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Lecture 16 Wed 10/21
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Bacterial Secretion Systems used in pathogenesis (cont) |
Secretion Handout & Appendix 1 of Salyers & Whitt |
Chapter 9; Todar |
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Lecture 17 Mon 10/26 |
GUEST LECTURE Bacterial exotoxins and endotoxin: |
Chapter 9; Todar |
Chapter 10 |
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Wed 10/28 |
Exam II – Lecture 10-16 |
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Fri 10/30 |
Nevada Day Recess |
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BACTERIAL PATHOGENS AND DISEASES IN HUMANS |
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Mon 11/02 |
Final Day to Drop |
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Lecture 18 Mon 11/02 |
Antimicrobial compounds |
Chapter 10 |
Chapter 11 |
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Lecture 19 Wed 11/04 |
How bacteria become resistant to antibiotics |
Chapter 11 |
Chapter 19 |
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Fri 11/06 |
SoLS Seminar: Dr. George Munson, Pathogenesis of Enterotoxigenic E. coli (ETEC) |
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Lecture 20 Mon 11/9 |
How bacteria become resistant to antibiotics |
Chapter 11 |
Chapter 19 |
Lecture 20 |
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11/11 |
VETERANS DAY RECESS |
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Lecture 21 Wed 11/16 |
Mycobacterium tuberculosis |
Chapter 19 |
Chapter 28; Todar |
Lecture 21 |
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Lecture 22 Mon 11/18 |
Diarrheagenic Escherichia coli |
Chapter 28; Todar |
Chapter 26; Todar |
Lecture 22 |
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Lecture 23 Wed 11/23 |
Diarrheagenic E. coli & Shigella spp. |
Chapter 28; Todar chapters |
Chapter 23 |
Lecture 23 |
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Lecture 24 Mon 11/25 |
Helicobacter pyloriPeptic ulcers/Duodenal ulcers and gastric cancer |
Chapter 23 |
Chapter 14; Todar |
Lecture 24 |
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11/26-27 |
THANKSGIVING RECESS |
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Lecture 25 Wed 11/30 |
Staphylococcal disease |
Chapter 14; Todar |
Chapter 15 & 18; Todar |
Lecture 25 |
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Lecture 26 Mon 12/2 |
Staphylococcal disease (cont) & Neisseria meningitidis and N. gonorrhoeae |
Lecture 26 |
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Mon 12/7 |
6pm-8pm FINAL EXAMINATION |
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