Brian P. Hedlund


Biology 351: Microbial Systems Fall 2008

 

Course description and prerequisites: Microbial Systems provides in-depth coverage of prokaryotic cell structure, function, genetics, diversity, ecology, and pathogenesis, with an emphasis on microbial metabolism, bacterial genetics and molecular mechanisms. Three hours lecture and three hours laboratory. Credit not allowed in both BIOL 251 and 351. Prerequisites: BIOL 189, BIOL 196, BIOL197, CHEM 121. 4 credits.

Class: Tuesday & Thursday11:30 am - 12:45 pm ; Bigelow Physics Building (BPB) 102

Course website: http://faculty.unlv.edu/hedlund/Bio351.htm

Webcampus site: All course lectures, up to date lecture grades, and selected other material are avaiable on Webcampus.

Required text: Brock Biology of Microorganisms, 12th Edition by Madigan, Martinko, Dunlap, and Clark

Instructor:
Dr. Brian Hedlund, Assistant Professor,
School of Life Sciences
Email: brian.hedlund@unlv.edu
Phone: 895-0809
Office hours: 306A White Hall; Tuesday 1:00-2:30 pm or by appointment

Class limit: 150

Labs: All labs are in 313 White Hall; Check your section for time and day.
L01 8:30 am-11:20 am Wed Jensara Clay
L02 11:30 am-2:20 pm Wed Caitlin Murphy
L03 2:30 pm-5:20 pm Wed Jensara Clay
L04 8:30 am-11:20 am Th Jensara Clay
L05 1:00 pm-3:50 pm Th Caitlin Murphy

Lab Coordinator: Shyama Malwane
Email: smalwane@unlv.edu
Phone: 895-1147
Office: 317 White Hall

Grading :
Lecture: 60% of your grade will come from the lecture section. Lecture grades will be determined by performance on 3 midterms and a comprehensive final exam (100 pts each). Your lowest exam grade, including the final, will be dropped from the calculation. Exams will cover material in assigned readings and material presented in class. The format will be 32 multiple-choice and 8 true/false. 10 points will come from a short answer section. There will be three themes in the short answer section and you will choose to answer questions from two of the themes. I will provide a scantron form but it is your responsibility to provide a number 2 pencil. More information will be given as the exam dates approach. Attendance at exams is required and an absence will result in a zero unless you (1) provide the instructor with reasonable justification of your absence before the exam (including religious holidays and official UNLV extracurricular activities) or (2) provide written documentation of the reason for your absence on official letterhead of a physician or legal authority within one week after the exam date. Eligible students will take a make-up exam. A make-up exam will not be similar to the original and it must be completed within 1 week of the original exam. A student who does not take a make-up exam within 1 week of the original exam will receive a zero for the test. Old exams are available on electronic reserves from: http://ereserves.library.unlv.edu.

Lab: 40% of your grade will come from the lab section. Your lab grade will be based on performance on the following: laboratory exams (240 points total; 2 exams), lab reports (120 points), unknown lab report (150 points); lab quizzes (80 points total), and correct use of microscope and lab coat (10 points). You must attend lab every week, including the first week of the semester.

Calculation of final grade: A percentage will be calculated for the lecture and the lab. Your lecture percentage will be multiplied by 0.6 and your lab percentage will be multiplied by 0.4. The resulting values will be added together to obtain your final grade. A, 100-90%; B, 89-80; C, 79-70; D, 69-60%; and F, <60%.

Extra credit: 1 percentage point of extra credit (added to the final grade) will be available to students based on attendance at the lecture. Attendance will be taken three times during the semester. Students who are present for all three unannounced days will receive the point. Students who are not present on one or more of the dates will be unable to receive the point regardless of the reason.

Grade posting: Exam grades and cumulative grades will be posted as soon as possible after each exam outside my office (306A White). Grades will be posted under the last four numbers of your student ID number (number beginning with L000…).

Lecture etiquette: During lecture you are expected to behave in a way that is not disruptive to the class. Eating is allowed but students should strive to eat quietly and not make a mess. Cell phones should be turned off.

Microbiology at UNLV: There is a growing core of microbiology courses at UNLV as well as a new microbiology concentration (see course catalog). For up to date information on course offerings in microbiology please visit the UNLV microbiology web page: http://faculty.unlv.edu/hjwing/microbiology.htm . Below is a list of upper division courses in microbiology.
Bio 409/609 Virology
(3 credits) taught fall semester
Instructor: Nick Nika ( joseph.nika@unlv.edu )
Bio 418/618 Microbial Ecology (3 credits) taught spring semester
Instructor: Brian Hedlund ( brian.hedund@unlv.edu )
Bio 453/653 Immunology (3 credits) taught fall semester
Instructor: Nick Nika ( joseph.nika@unlv.edu )
Bio 460 Microbial Physiology (3 credits) taught some spring semesters
Instructor: Dennis Bazylinski ( dennis.bazylinski@unlv.edu )
Bio 485/685 Bacterial Pathogenesis (3 credits) taught fall semester
Instructor: Helen Wing ( helen.wing@unlv.edu )
Bio 493/796 Topics in Microbiology (1 credit) taught fall and spring semesters
Instructors: Rotating.

Course schedule (subject to change)
Date Topic Text readings - Chapters (pages) Notes & outlines
Principles of microbiology - cell structure, function, basic central dogma
Aug 26 (Tu)

Syllabus discussion; Scope of microbiology

 

Notes, Outline 1
Aug 28 (Th)

Microorganisms and microbiology

1,2 (1-24; 26-33) Notes, Outline 2
Sept 2 (Tu)

Cell structure and function (Bacteria and Archaea)

4 (66-105)
Notes, Outline 3
Sept 4 (Th) Nutrition, culture, and metabolism 5 (107-140) Notes, Outline 4
Sept 9 (Tu) Microbial growth 6 (141-174) Notes, Outline 5
Sept 11 (Th) Molecular biology I - DNA structure and DNA replication 7 (175-188) Notes, Outline 6
Sept 16 (Tu) Molecular biology II - Transcription and Translation 7 (189-206) Notes, Outline 7
Sept 18 (Th) Archaeal molecular biology 8 (207-213) Notes, Outline 8
Sept 18 (Th) Review session 4-5 pm room CBC A112    
Sept 23 (Tu) Exam 1 (Lectures 1-8)    
Molecular biology of microorganisms, genetics, and genomics
Sept 25 (Th) Regulation of gene expression I 9 (225-236) Notes, Outline 9
Sept 30 (Tu) Regulation of gene expression II 9 (237-250) Notes, Outline 10
Oct 2 (Th) Virology 10 (251-277) Notes, Outline 11
Oct 3 (F) Final date to withdraw from class with 50% refund    
Oct 7 (Tu) Principles of bacterial genetics 11 (278-312) Notes, Outline 12
Oct 9 (Th) Genetic engineering I 12 (313-329) OUT OF TOWN Notes, Outline 13
Oct 14 (Tu) Genetic engineering II 12 (330-344) OUT OF TOWN Notes, Outline 14
Oct 16 (Th) Microbial genomics 13 (343-366) OUT OF TOWN Notes, Outline 15
Oct 21 (Tu) Catch up/review for exam No additional reading Notes, Outline 16
Oct 21 (Tu) Review session 4-5 pm room CBC A112    
Oct 23 (Th) Exam 2    
Microbial evolution, diversity, and ecology
Oct 28 (Tu) Microbial evolution and systematics 14 (367-393) Notes, Outline 17
Oct 30 (Th) Chemolithotrophs 20,14 (595-603; 403-410) Notes, Outline 18
Nov 3 (M) Final date to drop a class or change to audit!    
Nov 4 (Tu) Anaerobes 21,14 (624-640; 436-440) Notes, Outline 19
Nov 6 (Th) Phototrophs 20,14 (579-594; 401-402; 463-467; 474-476; 481-482) Notes, Outline 20
Nov 11 (Tu) No class - Veterans' Day

 

 
Nov 13 (Th) Major element cycles (C,N,S) and N fixation/Archaea 24,20 (694-703; 604-609); 17 (487-515)
Notes, Outline 21
Nov 18 (Tu) Human-microbe interactions 28 (811-839) Notes, Outline 22
Microbial interactions with humans
Nov 20 (Th) Oral microbiology

Brock 814-817; 122-124; 448-449; 477-480; 612-618; Ruby and Barbeau, 2002; Paster et al., 2006 (readings in webcampus Lecture 23 folder)

Notes, Outline 23
Nov 20 (Th) Review session 4-5 pm room CBC A112    
Nov 25 (Tu) Exam 3    
Nov 27 (Th) No class - Thanksgiving Day    
Dec 2(Tu) Role of microorganisms in obesity Brock 817-819; 472; 617-619 ; DiBaise et al., 2008; Backhed et al., 2004 (readings in webcampus Lecture 24 folder) Notes, Outline 24
Dec 4 (Th) HIV/AIDS Brock 271-273; 799-80; 944-945; Holmes, 2002 (Kallings, 2008 is optional) Notes, Outline 25
Dec 4 (Th) Review session 5:00-6:00 pm room CBC A112    

Dec 11 (Th) 10:10am-12:10pm

Comprehensive final exam    

Academic Misconduct – “Academic integrity is a legitimate concern for every member of the campus community; all share in upholding the fundamental values of honesty, trust, respect, fairness, responsibility and professionalism. By choosing to join the UNLV community, students accept the expectations of the Academic Misconduct Policy and are encouraged when faced with choices to always take the ethical path. Students enrolling in UNLV assume the obligation to conduct themselves in a manner compatible with UNLV's function as an educational institution.” An example of academic misconduct is plagiarism: “Using the words or ideas of another, from the Internet or any source, without proper citation of the sources.” See the “Student Academic Misconduct Policy” (approved December 9, 2005 ) located at: http://studentlife.unlv.edu/judicial/misconductPolicy.html .

Copyright. The University requires all members of the University Community to familiarize themselves and to follow copyright and fair use requirements. You are individually and solely responsible for violations of copyright and fair use laws. The university will neither protect nor defend you nor assume any responsibility for employee or student violations of fair use laws . Violations of copyright laws could subject you to federal and state civil penalties and criminal liability, as well as disciplinary action under University policies. To familiarize yourself with copyright and fair use policies, you are encouraged to visit the following website: http://www.unlv.edu/committees/copyright/ .

Disability Resource Center (DRC) – The Office of the Executive Vice President and Provost and Faculty Senate have endorsed the statement below to be included in all course syllabi. It is important to know that over two-thirds of the students in the DRC reported that the syllabus statement, often read aloud by the faculty during class, directed them to the DRC office. The Disability Resource Center (DRC) coordinates all academic accommodations for students with documented disabilities. The DRC is the official office to review and house disability documentation for students, and to provide them with an official Academic Accommodation Plan to present to the faculty if an accommodation is warranted. Faculty should not provide students accommodations without being in receipt of this plan. UNLV complies with the provisions set forth in Section 504 of the Rehabilitation Act of 1973 and the Americans with Disabilities Act of 1990, offering reasonable accommodations to qualified students with documented disabilities. If you have a documented disability that may require accommodations, you will need to contact the DRC for the coordination of services. The DRC is located in the Student Services Complex (SSC), Room 137, and the contact numbers are: Voice (702) 895-0866, TTY (702) 895-0652, fax (702) 895-0651. For additional information, please visit: http://studentlife.unlv.edu/disability/ .

Missed Class(es)/Student – As a general rule, a student missing a class or laboratory assignment because of observance of a religious holiday shall have the opportunity to make up missed work. Students must notify the instructor of anticipated absences by the last day of late registration, August 25, 2008 , to be assured of this opportunity. Faculty may give students an additional week, but are encouraged to set a clear deadline.
NOTE: Students who represent UNLV at any official extracurricular activity shall also have the opportunity to make up assignments, but the student must provide official written notification to the instructor no less than one week prior to the missed class(es). This policy shall not apply in the event that completing the assignment or administering the examination at an alternate time would impose an undue hardship on the instructor or the university that could reasonably have been avoided. There should be good faith effort by both faculty and student to come to a reasonable resolution. When disagreements regarding this policy do arise, they can be appealed to the department chair/unit director, college/school dean, and/or the Faculty Senate Academic Standards Committee. For purposes of definition, extracurricular activities may include, but are not limited to; band, drama, intercollegiate athletics, recruitment, and any other activity sanctioned by a college/school dean, and/or the Executive Vice President and Provost.

Rebelmail By policy, faculty and staff should e-mail students' Rebelmail accounts only. Rebelmail is UNLV's official e-mail system for students. It is one of the primary ways students receive official university communication. All UNLV students receive a Rebelmail account after admission to the university. Non-admitted students should contact the Student Help Desk at (702) 895-0761, in the Student Union Room 231, or by e-mail: studenthelp@unlv.edu . See http://rebelmail.unlv.edu/ for additional information.

UNLV Writing Center. One-on-one or small group assistance with writing is available free of charge to UNLV students at the Writing Center, located in CDC-301. Although walk-in consultations are sometimes available, students with appointments will receive priority assistance. Appointments may be made in person or by calling 895-3908. The student's Rebel ID Card, a copy of the assignment (if possible), and two copies of any writing to be reviewed are requested for the consultation. More information can be found at: http://writingcenter.unlv.edu/